"Come on, Spongebob, let's go knock each other's brains out." -Patrick

You look like someone who could really use some rubber nipples

Ren

I'm gonna be a monkey, a monkey monkey monkey, would you like to be one too?

Stimpy

Quick man, cling tenaciously to my buttocks

Powdered Toastman

No sir, I didn't like it.

Mr. Horse

I'm a laboratory mouse in the first stages of an elaborate plan to take over the world.

Brain

I wanna bury the hatchet... not in your pointed head boy!

-Foghorn Leghorn

Sideshow Bob: "Ah, the rack! My arch nemesis."

Bart: "I thought I was your arch nemesis?"

Sideshow Bob: " I do have a life outside of you Bart."

Brain: Are you pondering what I'm pondering?!

Pinky: Yeah, I think so, Brain, but I can't memorise the whole opera in yiddish.

Brain: Pinky, you are a threat to tolerance.

I don't think you're happy, kids...I'll teach you to be happy...I'l teach your grandmother to suck eggs!

"The Happy Happy Joy Joy Song"

"Man, this is weird. I hope I didn't brain my damage." -Homer

"See how wonderful life can be... when you're maniacal!" -Plankton

"Raaaaaaaarrrrrr!!! I am Spongebob, destroyer of evil!!" -Spongebob

Oh my God!!! They killed Kenny.

You bastards

~Stan and Kyle (South Park)

"Now all I need is a magic moustache and all my dreams will have come true." -Patrick